Chat^tm1Jrs
Targeted Allele Detail

Summary

• Symbol: Chat^tm1Jrs
• Name: choline acetyltransferase; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:3045899
• Synonyms: ChAT^flox
• Gene: Chat Location: Chr14:32130160-32187866 bp, - strand Genetic Position: Chr14, 19.4 cM
• Alliance: Chat^tm1Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91066
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were floxed and an frt-flanked neo inserted into intron 4 via homologous recombination. (J:91066)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chat Mutation: 57 strains or lines available

References

• Original: J:91066 Misgeld T, et al., Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron. 2002 Nov 14;36(4):635-48
• All: 28 reference(s)