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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpap2em1Gpt
endonuclease-mediated mutation 1, GemPharmatech
MGI:8474992
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbxw7tm1Iaai/Fbxw7tm1Iaai
Rpap2em1Gpt/Rpap2em1Gpt
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129 * C57BL/6 * C57BL/6JGpt * DBA MGI:8475016
cn2
 		Rpap2em1Gpt/Rpap2em1Gpt
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * C57BL/6JGpt * DBA MGI:8475014


Genotype
MGI:8475016
cn1
Allelic
Composition		 Fbxw7tm1Iaai/Fbxw7tm1Iaai
Rpap2em1Gpt/Rpap2em1Gpt
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6JGpt * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iaai mutation (1 available); any Fbxw7 mutation (81 available)
Rpap2em1Gpt mutation (0 available); any Rpap2 mutation (38 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:364423 )
N
• liver cysts and liver dysfunction observed in conditional knockout of Fbxw7 in the liver are rescued

adipose tissue
adipose tissue phenotype ( J:364423 )
N
• loss of Rpap2 expression rescues decreased body and epididymal fat in mice only lacking Fbxw7 expression in the liver




Genotype
MGI:8475014
cn2
Allelic
Composition		 Rpap2em1Gpt/Rpap2em1Gpt
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * C57BL/6JGpt * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpap2em1Gpt mutation (0 available); any Rpap2 mutation (38 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:364423 )
N
• liver development and function are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory