Phenotypes associated with this allele

• Allele Symbol: Nans^em1Xce
• Allele Name: endonuclease-mediated mutation 1, Xiaobo Cen
• Allele ID: MGI:8459976
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nans^em1Xce/Nans^em1Xce	C57BL/6N-Nans^em1Xce	MGI:8459980
ht2	Nans^em1Xce/Nans^+	C57BL/6N-Nans^em1Xce	MGI:8459981

Genotype
MGI:8459980

hm1

• Allelic Composition: Nans^em1Xce/Nans^em1Xce
• Genetic Background: C57BL/6N-Nans^em1Xce

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:343080 )

• no homozygotes are obtained

Genotype
MGI:8459981

ht2

• Allelic Composition: Nans^em1Xce/Nans⁺
• Genetic Background: C57BL/6N-Nans^em1Xce

behavior/neurological

impaired contextual conditioning behavior ( J:343080 )

• mice show impaired contextual fear conditioning, showing reductions in contextual freezing time after training

• however, cued fear conditioning is unaffected

increased thigmotaxis ( J:343080 )

• mice spend less time in the center area of the open-field, indicating elevated anxiety

• in the elevated plus maze, mice show a decrease in the number of entries and the time spent in open arms and increased time spend in closed arms, indicating anxiety-like behavior

• however, no difference in overall distance traveled in the open-field test is seen

cellular

abnormal neuron differentiation ( J:343080 )

• marker analysis at E14.5 shows reduced TBR2+ cells (intermediate progenitor cells) and TUJ1+ (early neuronal maker) areas in brain ventricular zone/outer subventricular zone (VZ/oSVZ) regions suggesting cortical neurogenesis impairment

nervous system

abnormal neuron differentiation ( J:343080 )

• marker analysis at E14.5 shows reduced TBR2+ cells (intermediate progenitor cells) and TUJ1+ (early neuronal maker) areas in brain ventricular zone/outer subventricular zone (VZ/oSVZ) regions suggesting cortical neurogenesis impairment