Phenotypes associated with this allele

• Allele Symbol: Gna14^em1Dlee
• Allele Name: endonuclease-mediated mutation 1, Daekee Lee
• Allele ID: MGI:8449338
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gna14^em1Dlee/Gna14^em1Dlee	C57BL/6N-Gna14^em1Dlee	MGI:8449340
cx2	Apc^Min/Apc^+ Gna14^em1Dlee/Gna14^em1Dlee	C57BL/6-Apc^Min Gna14^em1Dlee	MGI:8449342

Genotype
MGI:8449340

hm1

• Allelic Composition: Gna14^em1Dlee/Gna14^em1Dlee
• Genetic Background: C57BL/6N-Gna14^em1Dlee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:341358 )

• mice develop normally and exhibit normal reproduction

Genotype
MGI:8449342

cx2

• Allelic Composition: Apc^Min/Apc⁺; Gna14^em1Dlee/Gna14^em1Dlee
• Genetic Background: C57BL/6-Apc^Min Gna14^em1Dlee

digestive/alimentary system

intestine polyps ( J:341358 )

• while mice develop polyps, their number is reduced in the distal end of the small intestine but not in the proximal and middle parts, compared to single heterozygous Apc^Min mice

• in the distal intestine, the fraction of polyps that are 0.3 to 1 mm in size is increased and those that are 2-3 mm is decreased compared to that in single heterozygous Apc^Min mice

• mice exhibit a lower ratio of BrdU staining polyps indicating reduced cell proliferation and higher apoptosis than in single heterozygous Apc^Min mice

decreased alimentary system tumor incidence ( J:341358 )

• the number of polyps is reduced in the small intestine compared to single heterozygous Apc^Min mice, but no difference in polyp number is seen in the colon at 5 months of age

• the distal end of the small intestine shows the reduced number of polyps while the proximal and middle parts of the intestine show a similar number of polyps as single heterozygous Apc^Min mice

• mice have a higher proportion of low-grade adenoma and a lower proportion of high-grade adenoma, but no difference in the rate of adenocarcinoma compared to single heterozygous Apc^Min mice

neoplasm

decreased alimentary system tumor incidence ( J:341358 )

• the number of polyps is reduced in the small intestine compared to single heterozygous Apc^Min mice, but no difference in polyp number is seen in the colon at 5 months of age

• the distal end of the small intestine shows the reduced number of polyps while the proximal and middle parts of the intestine show a similar number of polyps as single heterozygous Apc^Min mice

• mice have a higher proportion of low-grade adenoma and a lower proportion of high-grade adenoma, but no difference in the rate of adenocarcinoma compared to single heterozygous Apc^Min mice