Phenotypes associated with this allele

• Allele Symbol: Ncstn^em1Btlr
• Allele Name: endonuclease-mediated mutation 1, Bruce Beutler
• Allele ID: MGI:8409915
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncstn^em1Btlr/Ncstn^em1Btlr	C57BL/6J-Ncstn^em1Btlr	MGI:8420527

Genotype
MGI:8420527

hm1

• Allelic Composition: Ncstn^em1Btlr/Ncstn^em1Btlr
• Genetic Background: C57BL/6J-Ncstn^em1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

rectal prolapse ( J:285752 )

• more prevalent in females than males

increased susceptibility to induced colitis ( J:285752 )

• lost 14% of body weight 10 days after dextran sodium sulfate (DSS) administration

• greater shortening of colon 10 days after dextran sodium sulfate (DSS) administration

embryo

embryo phenotype ( J:285752 )

N • mice born in expected Mendelian ratios

hematopoietic system

decreased transitional stage T2 B cell number ( J:285752 )

• fewer T2-MZP B cells in spleen

decreased B-1a cell number ( J:285752 )

• in peritoneum

decreased B-1b cell number ( J:285752 )

• in peritoneum

decreased marginal zone B cell number ( J:285752 )

decreased IgM level ( J:285752 )

immune system

increased susceptibility to induced colitis ( J:285752 )

• lost 14% of body weight 10 days after dextran sodium sulfate (DSS) administration

• greater shortening of colon 10 days after dextran sodium sulfate (DSS) administration

decreased transitional stage T2 B cell number ( J:285752 )

• fewer T2-MZP B cells in spleen

decreased B-1a cell number ( J:285752 )

• in peritoneum

decreased B-1b cell number ( J:285752 )

• in peritoneum

decreased marginal zone B cell number ( J:285752 )

abnormal humoral immune response ( J:285752 )

• impaired T cell-independent antibody response following immunization with NP-Ficoll

• normal T cell-dependent antibody response following immunization with OVA/alum

decreased IgM level ( J:285752 )

mortality/aging

mortality/aging ( J:285752 )

N • mice born in expected Mendelian ratios

pigmentation

hypopigmentation ( J:285752 )