All Phenotypes Erbb3<em1Dlee> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb3^em1Dlee
endonuclease-mediated mutation 1, Daekee Lee
MGI:8409366

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb3^em1Dlee/Erbb3^em1Dlee	C57BL/6J-Erbb3^em1Dlee	MGI:8409576
cx2	Apc^Min/Apc⁺ Erbb3^em1Dlee/Erbb3^em1Dlee	C57BL/6J-Erbb3^em1Dlee Apc^Min	MGI:8409574

Allelic Composition	Erbb3^em1Dlee/Erbb3^em1Dlee
Genetic Background	C57BL/6J-Erbb3^em1Dlee

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^em1Dlee mutation (0 available); any Erbb3 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:285396 )

N	• normal response to DSS-induced colitis

Allelic Composition	Apc^Min/Apc⁺ Erbb3^em1Dlee/Erbb3^em1Dlee
Genetic Background	C57BL/6J-Erbb3^em1Dlee Apc^Min

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (155 available)
Erbb3^em1Dlee mutation (0 available); any Erbb3 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased intestinal adenoma incidence ( J:285396 )

• fewer polyps in small intestine

• small intestine polyp size distribution skewed towards smaller-than-1-mm diameter bracket

• fewer high-grade adenomas in small intestine

• less distorted glandular structures in high-grade adenomas in small intestine

• normal number of polyps in colon

neoplasm