Erbb3^em1Dlee
Endonuclease-mediated Allele Detail

Summary

• Symbol: Erbb3^em1Dlee
• Name: erb-b2 receptor tyrosine kinase 3; endonuclease-mediated mutation 1, Daekee Lee
• MGI ID: MGI:8409366
• Synonyms: Erbb3^K740M
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^em1Dlee page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details:

  Lysine codon 740 (AAA) in exon 19 was changed to methionine (ATG) (p.K740M) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. The mutation renders the encoded protein kinase-dead. (J:285396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 46 strains or lines available

References

• Original: J:285396 Nguyen AT, et al., Kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis. Cancer Sci. 2020 Jan;111(1):137-147
• All: 1 reference(s)