Analysis Tools
growth/size/body
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• at E10.5, facial structures are severely underdeveloped due to regression of ectomesenchymal facial derivatives
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• at E10.5, embryos exhibit an overall reduction in body size
• however, heart size is relatively normal at E10.5
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• at E10.5, embryos show nearly complete absence of anterior facial ectomesenchyme
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embryo
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• at E10.5, embryos appear dysmorphic relative to littermate controls
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• at E10.5, embryos exhibit an overall reduction in body size
• however, heart size is relatively normal at E10.5
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• at E10.5, embryos show nearly complete absence of anterior facial ectomesenchyme
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• at E10.5, embryos show delayed development of cranial neural crest cell (CNCC) lineages
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craniofacial
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• at E10.5, facial structures are severely underdeveloped due to regression of ectomesenchymal facial derivatives
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nervous system
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• at E10.5, embryos show delayed development of cranial neural crest cell (CNCC) lineages
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• whole-mount immunostainings for SOX10 (a neural crest and glial marker), SOX2 (a marker of developing central nervous system), and 2H3 (also known as NEFM, a marker of peripheral nervous system) reveal structural alterations in the trigeminal ganglion
• however, trigeminal ganglia still form in their expected locations
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