All Phenotypes Gpx4<em1Marc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpx4^em1Marc
endonuclease-mediated mutation 1, Marcus Conrad
MGI:8350465

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx4^em1Marc/Gpx4^em1Marc	involves: C57BL/6J	MGI:8350582
cn2	Gpx4^em1Marc/Gpx4^tm2Marc Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:8350568
cn3	Gpx4^em1Marc/Gpx4^tm2Marc Tg(Camk2a-cre/ERT2)2Gsc/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:8350560

Allelic Composition	Gpx4^em1Marc/Gpx4^em1Marc
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^em1Marc mutation (0 available); any Gpx4 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:385850 )

• embryos die by stage E7.5

Allelic Composition	Gpx4^em1Marc/Gpx4^tm2Marc Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^em1Marc mutation (0 available); any Gpx4 mutation (80 available)
Gpx4^tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (1211 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased ferroptosis ( J:385850 )

• renal proximal tubule epithelia cell death by ferroptosis after tamoxifen administration

growth/size/body

weight loss ( J:385850 )

• owing to acute kidney failure after tamoxifen administration

homeostasis/metabolism

increased circulating creatinine level ( J:385850 )

• after tamoxifen administration

increased circulating bilirubin level ( J:385850 )

• after tamoxifen administration

increased circulating alanine transaminase level ( J:385850 )

• after tamoxifen administration

increased circulating aspartate transaminase level ( J:385850 )

• after tamoxifen administration

increased circulating lactate dehydrogenase level ( J:385850 )

• after tamoxifen administration

decreased circulating serum albumin level ( J:385850 )

• after tamoxifen administration

increased blood urea nitrogen level ( J:385850 )

• after tamoxifen administration

mortality/aging

premature death ( J:385850 )

• acute kidney failure leads to death 10-12 after tamoxifen administration

renal/urinary system

renal necrosis ( J:385850 )

• renal proximal tubule epithelia cell death by ferroptosis after tamoxifen administration

Allelic Composition	Gpx4^em1Marc/Gpx4^tm2Marc Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased vertical activity ( J:385850 )

• after tamoxifen administration

decreased locomotor activity ( J:385850 )

• after tamoxifen administration

cellular

increased ferroptosis ( J:385850 )

• cerebral cortex degeneration caused by ferroptosis of neurons

nervous system

decreased cerebral cortex cell number ( J:385850 )

• atrophy after tamoxifen administration

abnormal stratification in cerebral cortex ( J:385850 )

• disorganized after tamoxifen administration

thin cerebral cortex ( J:385850 )

• atrophy after tamoxifen administration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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