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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adarem1Dmsc
endonuclease-mediated mutation 1, Daniella M Schwartz
MGI:8346375
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adarem1Dmsc/Adarem1Dmsc involves: C57BL/6J * DBA/2 MGI:8346409
ht2
 		Adarem1Dmsc/Adar+ involves: C57BL/6J * DBA/2 MGI:8346390
cx3
 		Adarem1Dmsc/Adar+
Ifih1tm1.1Cln/Ifih1tm1.1Cln 		involves: 129X1/SvJ * C57BL/6J * DBA/2 MGI:8346412
cx4
 		Adarem1Dmsc/Adarem1Dmsc
Ifih1tm1.1Cln/Ifih1+ 		Not Specified MGI:8346414


Genotype
MGI:8346409
hm1
Allelic
Composition		 Adarem1Dmsc/Adarem1Dmsc
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Dmsc mutation (0 available); any Adar mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:379589 )
• embryos are recovered alive up to E12.5 but not beyond




Genotype
MGI:8346390
ht2
Allelic
Composition		 Adarem1Dmsc/Adar+
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Dmsc mutation (0 available); any Adar mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
microgliosis ( J:379589 )
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis
brain inflammation ( J:379589 )
• mice exhibit increased expression of IFN stimulated gene (ISG) mRNAs in brain of 6-week-old mice indicative of brain inflammation; ISG expression rapidly increases in young mice and is predominantly in deep brain areas indicating neuroinflammation

nervous system
astrocytosis ( J:379589 )
• GFAP staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased astrocytosis
microgliosis ( J:379589 )
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis
brain inflammation ( J:379589 )
• mice exhibit increased expression of IFN stimulated gene (ISG) mRNAs in brain of 6-week-old mice indicative of brain inflammation; ISG expression rapidly increases in young mice and is predominantly in deep brain areas indicating neuroinflammation

hematopoietic system
microgliosis ( J:379589 )
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis

cellular
astrocytosis ( J:379589 )
• GFAP staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased astrocytosis
microgliosis ( J:379589 )
• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis

mortality/aging
mortality/aging ( J:379589 )
N
• mice exhibit normal survival, development and body size

behavior/neurological
behavior/neurological phenotype ( J:379589 )
N
• mice do not exhibit neurologic phenotypes, with normal startle response and gait, and no muscle spasms, dystonia or seizures




Genotype
MGI:8346412
cx3
Allelic
Composition		 Adarem1Dmsc/Adar+
Ifih1tm1.1Cln/Ifih1tm1.1Cln
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Dmsc mutation (0 available); any Adar mutation (83 available)
Ifih1tm1.1Cln mutation (5 available); any Ifih1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:379589 )
N
• expression of IFN stimulated gene (ISG) mRNAs in brain of 2-week-old mice is comparable to wild-type controls, indicating rescue of the brain inflammation phenotype seen in single Adarem1Dmsc heterozygotes




Genotype
MGI:8346414
cx4
Allelic
Composition		 Adarem1Dmsc/Adarem1Dmsc
Ifih1tm1.1Cln/Ifih1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Dmsc mutation (0 available); any Adar mutation (83 available)
Ifih1tm1.1Cln mutation (5 available); any Ifih1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:379589 )
• pups only survive to 2-3 weeks, with only one mouse surviving to 9 weeks

growth/size/body
postnatal growth retardation ( J:379589 )
• pups exhibit severe growth retardation, with smaller body size becoming noticeable 3 days after birth and became increasingly pronounced after 1 week of age

immune system
brain inflammation ( J:379589 )
• expression of IFN stimulated gene (ISG) mRNAs in brain are reduced compared to single Adarem1Dmsc homozygotes but are still increased compared to wild-type controls

nervous system
brain inflammation ( J:379589 )
• expression of IFN stimulated gene (ISG) mRNAs in brain are reduced compared to single Adarem1Dmsc homozygotes but are still increased compared to wild-type controls




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Send questions and comments to User Support. 		last database update
05/26/2026
MGI 6.24 		The Jackson Laboratory