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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfe2l2tm1.1Gne
targeted mutation 1.1, Genentech
MGI:8322213
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nfe2l2tm1.1Gne/Nfe2l2tm1.1Gne
Speer6-ps1Tg(Alb-cre)21Mgn/0 		involves: C57BL/6 * C57BL/6N * DBA MGI:8322562


Genotype
MGI:8322562
cn1
Allelic
Composition		 Nfe2l2tm1.1Gne/Nfe2l2tm1.1Gne
Speer6-ps1Tg(Alb-cre)21Mgn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1.1Gne mutation (0 available); any Nfe2l2 mutation (94 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged liver ( J:353988 )
• from age 4 weeks; maximal at 8 weeks

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:353988 )
N
• normal serum alanine aminotransferase levels
abnormal enzyme/coenzyme level ( J:353988 )
• increased hepatic NADPH level and NADPH-to-NADP ratio

liver/biliary system
liver/biliary system phenotype ( J:353988 )
N
• no liver damage (normal serum alanine aminotransferase levels)
enlarged liver ( J:353988 )
• from age 4 weeks; maximal at 8 weeks
abnormal hepatocyte morphology ( J:353988 )
• cytoplasmic clearing at ages 8 and 16 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/14/2026
MGI 6.24 		The Jackson Laboratory