Phenotypes associated with this allele

• Allele Symbol: Ccnj^tm1.1Ota
• Allele Name: targeted mutation 1.1, Osamu Takeuchi
• Allele ID: MGI:8321900
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccnj^tm1.1Ota/Ccnj^tm1.1Ota Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:8322204

Genotype
MGI:8322204

cn1

• Allelic Composition: Ccnj^tm1.1Ota/Ccnj^tm1.1Ota; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:362716 )

• mice are protected against systemic Staphylococcus aureus bacterial infection, with lower fatality after infection

digestive/alimentary system

increased susceptibility to induced colitis ( J:362716 )

• mice treated with azoxymethane-dextran sodium sulfate (AOM-DSS) to induce colitis-induced cancer lose more body weight and have a greater tumor burden in the colon

hematopoietic system

abnormal neutrophil physiology ( J:362716 )

• thioglycolate-elicited peritoneal neutrophils produce more IL-6 and less IL-10 in response to LPS and Pam3CSK4

abnormal macrophage physiology ( J:362716 )

• peritoneal macrophages and bone marrow derived macrophages show enhanced expression of proinflammatory genes (Il6, Ifnb, and Cxcl1) and reduced Il10 expression upon LPS stimulation

• macrophages show increased production of IL-6 and IL-12p40 upon stimulation with the TLR ligands LPS and Pam3CSK4

• however, the proliferation of macrophages in response to a mitogen, macrophage colony-stimulating factor (M-CSF) is not altered

abnormal macrophage chemotaxis ( J:362716 )

• the proportion of CD45+ immune cells in the MC38 tumors is comparable to controls despite differences in tumor size, but the abundance of F4/80+CD11b+ tumor associated macrophages (TAMs) is increased, while other immune subsets such as T cells, natural killer (NK) cells, natural killer T (NKT) cells, and neutrophils are not altered, and proportions of Ki67+ TAMS are comparable, suggesting that macrophage recruitment, but not proliferation, is affected

homeostasis/metabolism

increased cytokine level ( J:362716 )

• mice systematically inoculated with S. aureus show increased production of proinflammatory cytokines such as IL-6 and IL-12p40 in serum

• mice exposed to LPS show increased proinflammatory cytokines in serum

increased incidence of tumors by chemical induction ( J:362716 )

• mice treated with azoxymethane-dextran sodium sulfate (AOM-DSS) to induce colitis-induced cancer lose more body weight and have a greater tumor burden in the colon

immune system

increased susceptibility to induced colitis ( J:362716 )

• mice treated with azoxymethane-dextran sodium sulfate (AOM-DSS) to induce colitis-induced cancer lose more body weight and have a greater tumor burden in the colon

abnormal neutrophil physiology ( J:362716 )

• thioglycolate-elicited peritoneal neutrophils produce more IL-6 and less IL-10 in response to LPS and Pam3CSK4

abnormal macrophage physiology ( J:362716 )

• peritoneal macrophages and bone marrow derived macrophages show enhanced expression of proinflammatory genes (Il6, Ifnb, and Cxcl1) and reduced Il10 expression upon LPS stimulation

• macrophages show increased production of IL-6 and IL-12p40 upon stimulation with the TLR ligands LPS and Pam3CSK4

• however, the proliferation of macrophages in response to a mitogen, macrophage colony-stimulating factor (M-CSF) is not altered

abnormal macrophage chemotaxis ( J:362716 )

• the proportion of CD45+ immune cells in the MC38 tumors is comparable to controls despite differences in tumor size, but the abundance of F4/80+CD11b+ tumor associated macrophages (TAMs) is increased, while other immune subsets such as T cells, natural killer (NK) cells, natural killer T (NKT) cells, and neutrophils are not altered, and proportions of Ki67+ TAMS are comparable, suggesting that macrophage recruitment, but not proliferation, is affected

increased cytokine level ( J:362716 )

• mice systematically inoculated with S. aureus show increased production of proinflammatory cytokines such as IL-6 and IL-12p40 in serum

• mice exposed to LPS show increased proinflammatory cytokines in serum

increased susceptibility to endotoxin shock ( J:362716 )

• mice are highly susceptible to LPS shock, with decreased survival rate and increased proinflammatory cytokines in serum

decreased susceptibility to bacterial infection ( J:362716 )

• mice are protected against systemic Staphylococcus aureus bacterial infection, with lower fatality after infection compared to controls and decreased bacterial burden in multiple organs

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:362716 )

• mice are protected against systemic Staphylococcus aureus bacterial infection, with lower fatality after infection

neoplasm

increased incidence of tumors by chemical induction ( J:362716 )

• mice treated with azoxymethane-dextran sodium sulfate (AOM-DSS) to induce colitis-induced cancer lose more body weight and have a greater tumor burden in the colon

increased tumor growth/size ( J:362716 )

• after syngeneic MC38 colorectal tumor xenograft, mice show faster tumor growth and bare larger tumors than controls

• after B16-F10 melanoma tumor xenografts, mice show more rapid tumor growth

cellular

abnormal macrophage chemotaxis ( J:362716 )

• the proportion of CD45+ immune cells in the MC38 tumors is comparable to controls despite differences in tumor size, but the abundance of F4/80+CD11b+ tumor associated macrophages (TAMs) is increased, while other immune subsets such as T cells, natural killer (NK) cells, natural killer T (NKT) cells, and neutrophils are not altered, and proportions of Ki67+ TAMS are comparable, suggesting that macrophage recruitment, but not proliferation, is affected