Ccnj^tm1.1Ota
Targeted Allele Detail

Summary

• Symbol: Ccnj^tm1.1Ota
• Name: cyclin J; targeted mutation 1.1, Osamu Takeuchi
• MGI ID: MGI:8321900
• Synonyms: Ccnj^fl
• Gene: Ccnj Location: Chr19:40819723-40837016 bp, + strand Genetic Position: Chr19, 34.26 cM
• Alliance: Ccnj^tm1.1Ota page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:362716
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistance gene was inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 3. The neomycin resistance gene was removed via cre-mediated recombination in the ES cells, leaving exon 3 floxed. (J:362716)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnj Mutation: 19 strains or lines available

References

• Original: J:362716 Chong YK, et al., Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism. Sci Signal. 2022 Apr 12;15(729):eabm5011
• All: 1 reference(s)