Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Tmem25)1Smoc
• Allele Name: transgene insertion 1, Shanghai Model Organisms Center
• Allele ID: MGI:8288702
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-Tmem25)1Smoc/0 Tg(MMTV-PyVT)634Mul/0	FVB-Tg(CAG-Tmem25)1Smoc Tg(MMTV-PyVT)634Mul	MGI:8288741

Genotype
MGI:8288741

cx1

• Allelic Composition: Tg(CAG-Tmem25)1Smoc/0; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: FVB-Tg(CAG-Tmem25)1Smoc Tg(MMTV-PyVT)634Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:335171 )

♀ • mice show suppression of triple-negative breast tumor growth and lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

decreased metastatic potential ( J:335171 )

♀ • mice show suppression of triple-negative breast tumor lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

♀ • the normalized lung metastasis to primary tumor burden is decreased

decreased tumor cell proliferation ( J:335171 )

♀ • cell proliferation is suppressed in spontaneous breast tumors

mortality/aging

increased tumor-free survival time ( J:335171 )

♀ • overall survival time is prolonged compared to single Tg(MMTV-PyVT)634Mul/0 mice

integument

decreased mammary gland tumor incidence ( J:335171 )

♀ • mice show suppression of triple-negative breast tumor growth and lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:335171 )

♀ • mice show suppression of triple-negative breast tumor growth and lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice