Phenotypes associated with this allele

• Allele Symbol: Taf2^em1Dsar
• Allele Name: endonuclease-mediated mutation 1, Devanand Sarkar
• Allele ID: MGI:8275769
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+ Taf2^em1Dsar/Taf2^em1Dsar	involves: C57BL/6 * DBA	MGI:8275771

Genotype
MGI:8275771

cn1

• Allelic Composition: Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺; Taf2^em1Dsar/Taf2^em1Dsar
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:376591 )

• 6 months after treatment with N-nitrosodiethylamine (DEN) and feeding of either a control or high fat high sugar diet, mice become moribund unlike similarly treated wild-type mice

liver/biliary system

liver fibrosis ( J:376591 )

• at one month, show increased staining collagen I and alpha-smooth muscle actin

abnormal liver physiology ( J:376591 )

• slight increase in markers of apoptosis but no overt phenotype

liver inflammation ( J:376591 )

• at one month of age show increased staining for macrophage and neutrophil markers

neoplasm

increased incidence of tumors by chemical induction ( J:376591 )

• following treatment with N-nitrosodiethylamine (DEN) and fed either a control or high fat high sugar diet, mice show an increased tumor burden and liver weight to body weight ratio

• high fat high sugar diet significantly augmented the difference in liver tumor burden

• liver tumors show loss of architecture and hepatocyte ballooning indicative of hepatocelluar carcinoma

immune system

liver inflammation ( J:376591 )

• at one month of age show increased staining for macrophage and neutrophil markers

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:376591 )

• 6 months after treatment with N-nitrosodiethylamine (DEN) and feeding of either a control or high fat high sugar diet, mice become moribund unlike similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:376591 )

• following treatment with N-nitrosodiethylamine (DEN) and fed either a control or high fat high sugar diet, mice show an increased tumor burden and liver weight to body weight ratio

• high fat high sugar diet significantly augmented the difference in liver tumor burden

• liver tumors show loss of architecture and hepatocyte ballooning indicative of hepatocelluar carcinoma