All Phenotypes Rbpms2<tm2.1Thbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rbpms2^tm2.1Thbr
targeted mutation 2.1, Thomas Braun
MGI:8226421

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6 * FVB/N	MGI:8226709
cn2	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(myl7.L-cre)1118Tmhn/0	involves: 129 * C57BL/6 * MF1	MGI:8226708
cn3	Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr	involves: 129S4/SvJae * C57BL/6	MGI:8226711
cn4	Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:8226672
cn5	Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(myl7.L-cre)1118Tmhn/0	involves: 129S4/SvJae * C57BL/6 * MF1	MGI:8226669

Allelic Composition	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm11(CAG-tdTomato*,-GFP*)Nat} mutation (1 available); any Gt(ROSA)26Sor mutation (1031 available)
Rbpms2^tm2.1Thbr mutation (0 available); any Rbpms2 mutation (202 available)
Rbpms^tm1.1Thbr mutation (0 available); any Rbpms mutation (493 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:369747 )

• at E16.5 the nuclei are irregular in outline and size or associated with micronuclei

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

muscle

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

cellular

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

abnormal cell nucleus morphology ( J:369747 )

• at E16.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

increased micronucleus incidence ( J:369747 )

• at E16.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

Allelic Composition	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(myl7.L-cre)1118Tmhn/0
Genetic Background	involves: 129 * C57BL/6 * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:369747 )

• at E12.5 the nuclei are irregular in outline and size or associated with micronuclei

cellular

abnormal cell nucleus morphology ( J:369747 )

• at E12.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

increased micronucleus incidence ( J:369747 )

• at E12.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

Allelic Composition	Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpms2^tm2.1Thbr mutation (0 available); any Rbpms2 mutation (202 available)
Rbpms^tm1.1Thbr mutation (0 available); any Rbpms mutation (493 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:369747 )

• following adeno-cre infection of isolated E14.5 cardiomyocytes, proliferating cardiomyocytes show a higher rate of nuclear defects compared to non-proliferating cells

• following adeno-cre infection of isolated E14.5 cardiomyocytes, spindle and chromosome distribution defects are seen with an increase in the percentage of cells with unaligned chromosomes, multi-polar spindle formation, chromatin bridges, and lagging chromosomes

• following adeno-cre infection of isolated E14.5 cardiomyocytes, cells with micronuclei in telophase

cellular

abnormal cell nucleus morphology ( J:369747 )

• following adeno-cre infection of isolated E14.5 cardiomyocytes, proliferating cardiomyocytes show a higher rate of nuclear defects compared to non-proliferating cells

abnormal mitosis ( J:369747 )

• following adeno-cre infection of isolated E14.5 cardiomyocytes, cells with micronuclei in telophase

abnormal mitotic spindle morphology ( J:369747 )

• following adeno-cre infection of isolated E14.5 cardiomyocytes, an increase in the percentage of cells with multi-polar spindle formations are seen

Allelic Composition	Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial trabeculae morphology ( J:369747 )

• slight disorganization of the layer

thin ventricle myocardium compact layer ( J:369747 )

• reduced thickness in the ventricles and septum at E16.5 and E18.5

• however, the thickness of the trabecular layer is not altered

abnormal fetal cardiomyocyte morphology ( J:369747 )

• disruption of sarcomere integrity in cardiomyocytes at E16.5

• nuclear abnormalities

abnormal fetal cardiomyocyte physiology ( J:369747 )

• expression analysis indicates defects in cardiomyocyte-specific alternative splicing

muscle

abnormal myocardial trabeculae morphology ( J:369747 )

• slight disorganization of the layer

thin ventricle myocardium compact layer ( J:369747 )

• reduced thickness in the ventricles and septum at E16.5 and E18.5

• however, the thickness of the trabecular layer is not altered

abnormal sarcomere morphology ( J:369747 )

• disruption of sarcomere integrity in cardiomyocytes at E16.5

Allelic Composition	Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(myl7.L-cre)1118Tmhn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial trabeculae morphology ( J:369747 )

• slight disorganization of the layer

thin ventricle myocardium compact layer ( J:369747 )

• reduced thickness in the ventricles and septum at E14.5

• however, the thickness of the trabecular layer is not altered

muscle

abnormal myocardial trabeculae morphology ( J:369747 )

• slight disorganization of the layer

thin ventricle myocardium compact layer ( J:369747 )

• reduced thickness in the ventricles and septum at E14.5

• however, the thickness of the trabecular layer is not altered

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