Rbpms^tm1.1Thbr
Targeted Allele Detail

Summary

• Symbol: Rbpms^tm1.1Thbr
• Name: RNA binding protein gene with multiple splicing; targeted mutation 1.1, Thomas Braun
• MGI ID: MGI:8226420
• Synonyms: Rbpms^flox
• Gene: Rbpms Location: Chr8:34272671-34419891 bp, - strand Genetic Position: Chr8, 20.85 cM
• Alliance: Rbpms^tm1.1Thbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:369747
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 1.1kb upstream of the start codon and an FRT-PGK-EM7-neobpA-FRT-loxP cassette was inserted 1.45kb downstream of the start codon via homologous recombination. Flp mediated recombination removed the neo geneleaving a 2.55kb genomic region including the promoter and coding exon 1 floxed. (J:369747)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbpms Mutation: 493 strains or lines available

References

• Original: J:369747 Lin S, et al., Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice. Dev Cell. 2025 Jun 24
• All: 1 reference(s)