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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab30em1Mwol
endonuclease-mediated mutation 1, Michael J Wolfgang
MGI:8210453
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rab30em1Mwol/Rab30em1Mwol
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA MGI:8210455
cn2
 		Cpt2tm1Mwol/Cpt2tm1Mwol
Rab30em1Mwol/Rab30em1Mwol
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA MGI:8210461


Genotype
MGI:8210455
cn1
Allelic
Composition		 Rab30em1Mwol/Rab30em1Mwol
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab30em1Mwol mutation (0 available); any Rab30 mutation (16 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:348980 )
• males are larger by 1.77g compared to controls

liver/biliary system
liver/biliary system phenotype ( J:348980 )
N
• no change in liver triglycerides or lipid levels in the fasted state

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:348980 )
N
• no significant differences in serum metabolites unlike in whole body knockout mice
increased circulating glucose level ( J:348980 )
• increased fasted blood glucose




Genotype
MGI:8210461
cn2
Allelic
Composition		 Cpt2tm1Mwol/Cpt2tm1Mwol
Rab30em1Mwol/Rab30em1Mwol
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt2tm1Mwol mutation (0 available); any Cpt2 mutation (28 available)
Rab30em1Mwol mutation (0 available); any Rab30 mutation (16 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:348980 )
N
• unlike in fasted mice with liver specific loss of Cpt2 alone, double knockout mice have a reversal of the increase in triglycerides and cholesterol levels back to control levels
decreased circulating glucose level ( J:348980 )
• in fasted females compared to controls
decreased circulating ketone body level ( J:348980 )
• decrease in fasting ketone bodies
increased circulating free fatty acids level ( J:348980 )
• compared to fasted controls and fasted mice with hepatic specific loss of Cpt2 only
• differences are not seen in the fed state

liver/biliary system
enlarged liver ( J:348980 )
• larger and paler in fasted mice
abnormal hepatocyte morphology ( J:348980 )
• in fasted mice hepatocytes appear swollen and lipid laden
hepatic steatosis ( J:348980 )
• fasting induced lipid accumulation
pale liver ( J:348980 )
• in fasted mice

growth/size/body
enlarged liver ( J:348980 )
• larger and paler in fasted mice




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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory