Phenotypes associated with this allele

• Allele Symbol: Mycbpap^em1Maik
• Allele Name: endonuclease-mediated mutation 1, Masahito Ikawa
• Allele ID: MGI:8209213
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mycbpap^em1Maik/Mycbpap^em1Maik	involves: C57BL/6 * DBA/2	MGI:8209229

Genotype
MGI:8209229

hm1

• Allelic Composition: Mycbpap^em1Maik/Mycbpap^em1Maik
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:367324 )

♂ • sperm tails are almost absent in stage II-III and stage VII-VIII seminiferous tubules

short sperm flagellum ( J:367324 )

♂ • sperm tail length ranges from ~20 to 120 um, significantly shorter than in controls

oligozoospermia ( J:367324 )

♂ • spermatoza are nearly absent in the epididymis

abnormal sperm head morphology ( J:367324 )

♂ • round heads

abnormal spermatid morphology ( J:367324 )

♂ • abnormal morphology is seen starting at step 9

♂ • in step 9 spermatids, the centrosome fails to correctly dock onto the nuclear envelope

♂ • acetylated tubulin accumulates around the round spermatid but not in the correct position

decreased elongated spermatid number ( J:367324 )

♂ • step 13-16 elongated spermatids are almost absent

elongated manchette ( J:367324 )

♂ • abnormally long manchette

increased male germ cell apoptosis ( J:367324 )

♂ • signs of apoptosis are seen in seminiferous tubules

♂ • increase in the percentage of seminiferous tubules carrying apoptotic spermatids

immotile sperm ( J:367324 )

♂ • mature spermatozoa show no motility

small testis ( J:367324 )

♂

decreased testis weight ( J:367324 )

♂

abnormal spermiogenesis ( J:367324 )

♂ • in stage VII seminiferous tubules a few of the step 16 spermatids are intermixed with step 7 spermatids and their tails are not visible in sections unlike in controls

♂ • step 13-16 elongated spermatids are almost absent

male infertility ( J:367324 )

♂ • when mated to wild-type females no pups were produced despite copulation occurring

cellular

abnormal sperm flagellum morphology ( J:367324 )

♂ • sperm tails are almost absent in stage II-III and stage VII-VIII seminiferous tubules

short sperm flagellum ( J:367324 )

♂ • sperm tail length ranges from ~20 to 120 um, significantly shorter than in controls

oligozoospermia ( J:367324 )

♂ • spermatoza are nearly absent in the epididymis

abnormal sperm head morphology ( J:367324 )

♂ • round heads

abnormal spermatid morphology ( J:367324 )

♂ • abnormal morphology is seen starting at step 9

♂ • in step 9 spermatids, the centrosome fails to correctly dock onto the nuclear envelope

♂ • acetylated tubulin accumulates around the round spermatid but not in the correct position

decreased elongated spermatid number ( J:367324 )

♂ • step 13-16 elongated spermatids are almost absent

elongated manchette ( J:367324 )

♂ • abnormally long manchette

increased male germ cell apoptosis ( J:367324 )

♂ • signs of apoptosis are seen in seminiferous tubules

♂ • increase in the percentage of seminiferous tubules carrying apoptotic spermatids

immotile sperm ( J:367324 )

♂ • mature spermatozoa show no motility

endocrine/exocrine glands

small testis ( J:367324 )

♂

decreased testis weight ( J:367324 )

♂