Mycbpap^em1Maik
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mycbpap^em1Maik
• Name: MYCBP associated protein; endonuclease-mediated mutation 1, Masahito Ikawa
• MGI ID: MGI:8209213
• Synonyms: Mycbpap^em1
• Gene: Mycbpap Location: Chr11:94392173-94412568 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Mycbpap^em1Maik page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs (5'-TCCAGAAAAGAAGCGGGCGA-3 and 5-TAAAGTCTGCAAGCCGGGAC-3) targeting exon 2 and exon 18 created an 11,419 bp deletion spanning exons 2 - 18. (J:367324)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycbpap Mutation: 38 strains or lines available

References

• Original: J:367324 Wang H, et al., MYCBPAP is a central apparatus protein required for centrosome-nuclear envelope docking and sperm tail biogenesis in mice. J Cell Sci. 2024 Aug 15;137(16):jcs261962
• All: 1 reference(s)