Analysis Tools
behavior/neurological
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• mice exhibit normal walking and grooming behavior in the first 5 min of the open field test, regardless of lighting conditions, and show normal motor function in the rotarod test
• no major changes are detected in anxiety (light/dark box test and elevated plus maze test), in depression (forced swim test), or in addiction (sucrose preference test) relative to wild-type controls
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• mice rear less with no change in total distance travelled during the training phase of the object recognition test and exhibit poorer displaced object memory
• however, novel object recognition is unaffected
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• under dim lighting, mice rear less frequently and spend less time in the center of the novel arenas in the open field test
• under dim lighting, mice exhibit fewer total visits (crossing events) to the novel frontiers in a New Frontier exploration task, and show fewer hole-pokes in the hole-board task
• however, the habituation rate and total horizontal activity are normal under both dim and bright lighting in the open field test
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• mice fail to display an association between exploratory rearing activity and spatial memory (preference to displaced objects) in the object recognition test, indicating that they lack a self-directed exploration learning bonus
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• under dim lighting, mice exhibit reduced rearing activity in the open field test
• mice rear less during the training phase of the object recognition test
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growth/size/body
| N |
• 8-week-old mice fed normal chow ad libitum show no body weight difference relative to wild-type and heterozygous littermates
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