All Phenotypes Ube2f<tm1c(EUCOMM)Hmgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ube2f^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7738243

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: 129S4/SvJae * C57BL/6	MGI:7738284
cn2	Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: 129S4/SvJae * C57BL/6J * C57BL/6N	MGI:7738261
cn3	Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: C57BL/6J * C57BL/6N	MGI:7738262

Allelic Composition	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diras2^em1Gpt mutation (0 available); any Diras2 mutation (20 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (29 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

neoplasm

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

Allelic Composition	Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJae * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (29 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:348744 )

• relative to mutant mice wild-type for Ube2f indicating improved growth

neoplasm

decreased tumor incidence ( J:348744 )

• decrease in pancreatic intraepithelial neoplasia at all 3 stages relative to mutant mice wild-type for Ube2f at 4, 6, and 9 months of age

• by 12 months of age there is an increase in stage I but decrease in stage II and III lesions in the pancreas indicating a delay in pancreatic tumor progression

endocrine/exocrine glands

small pancreas ( J:348744 )

• relative to mutant mice wild-type for Ube2f

decreased susceptibility to induced pancreatitis ( J:348744 )

• decrease in disruption of acinar cell population in cerulein-induced pancreatitis

• fewer infiltrations of leukocytes and neutrophils at 3d after cerulein treatment

Allelic Composition	Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (29 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:348744 )

N	• no detectable change in cerulein-induced pancreatitis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24