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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ube2sem1Ysun
endonuclease-mediated mutation 1, Yi Sun
MGI:7707820
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Ube2sem1Ysun/Ube2sem1Ysun 		involves: 129S4/SvJae MGI:7710917


Genotype
MGI:7710917
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Ube2sem1Ysun/Ube2sem1Ysun
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Ube2sem1Ysun mutation (0 available); any Ube2s mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:333347 )
• mice intratracheally administered an adenovirus expressing cre recombinase (Ad-cre) develop lung tumors with a survival rate similar to single mutant Kras homozygous mice

respiratory system
increased lung tumor incidence ( J:333347 )
• mice intratracheally administered an adenovirus expressing cre recombinase (Ad-cre) develop lung tumors with a survival rate similar to single mutant Kras homozygous mice

mortality/aging
decreased tumor-free survival time ( J:333347 )
• mice intratracheally administered Ad-cre have a median survival time as single mutant Kras homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory