About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Orai3em1.1Treb
endonuclease-mediated mutation 1.1, Mohamed Trebak
MGI:7625689
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb 		involves: BALB/c * C57BL/6J * C57BL/6N MGI:7625702
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Orai3em1.1Treb/Orai3em1.1Treb 		involves: BALB/c * C57BL/6J * C57BL/6N MGI:7625703


Genotype
MGI:7625702
cn1
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb
Genetic
Background		 involves: BALB/c * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Orai1tm1Smua mutation (0 available); any Orai1 mutation (22 available)
Orai3em1.1Treb mutation (0 available); any Orai3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:345485 )
N
• immune responses to influenza A infection are similar to controls
abnormal B cell physiology ( J:345485 )
• store-operated Ca2+ entry in B cells is reduced by~83%
• anti-IgM mediated NFAT1 translocation is significantly reduced
abnormal B cell activation ( J:345485 )
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted
decreased B cell proliferation ( J:345485 )
• decrease in both proliferation and viablity of cells following anti-IgM stimulation

hematopoietic system
abnormal B cell physiology ( J:345485 )
• store-operated Ca2+ entry in B cells is reduced by~83%
• anti-IgM mediated NFAT1 translocation is significantly reduced
abnormal B cell activation ( J:345485 )
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted
decreased B cell proliferation ( J:345485 )
• decrease in both proliferation and viablity of cells following anti-IgM stimulation

homeostasis/metabolism
abnormal calcium ion homeostasis ( J:345485 )
• store-operated Ca2+ entry in B cells is reduced by~83%

cellular
decreased B cell proliferation ( J:345485 )
• decrease in both proliferation and viablity of cells following anti-IgM stimulation




Genotype
MGI:7625703
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Orai3em1.1Treb/Orai3em1.1Treb
Genetic
Background		 involves: BALB/c * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Orai3em1.1Treb mutation (0 available); any Orai3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:345485 )
N
• store-operated Ca2+ entry in B cells is not significantly different from controls
abnormal B cell activation ( J:345485 )
• anti-IgM stimulated proliferation is similar to control but viability is increased

hematopoietic system
abnormal B cell activation ( J:345485 )
• anti-IgM stimulated proliferation is similar to control but viability is increased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory