Analysis Tools
homeostasis/metabolism
 N |
• do not show glucose intolerance at 12 weeks of age
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Allele Symbol Allele Name Allele ID |
Gpcpd1tm1c(EUCOMM)Hmgu targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH MGI:7610680 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• do not show glucose intolerance at 12 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• do not show glucose intolerance at 12 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• normal muscle development, morphology, and size at 6 and 20 months of age
• distribution of fiber type, myofiber size, muscle and mitochondrial ultrastructure, and muscle strength are similar to controls at 20 months of age
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• increased uptake in skeletal and cardiac muscle at 12 weeks of age
• no change in glucose uptake in white fat, subcutaneous fat, brown fat, or liver
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• at 12 weeks of age
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• decreased muscle glycogen levels at 20 months of age
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N |
• blood insulin levels are similar to controls
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• increased insulin release at 12 weeks of age
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• fed and fasting hyperglycemia at 20 months of age but not at 12 weeks of age
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• severe glucose intolerance at 12 weeks and 20 months of age
• severe defect in glucose clearance after 10 weeks on a high-sugar diet or high fat diet that is worse than in diet matched controls
• however, no difference in weight gain is seen in mice on a high sugar or high fat diet compared to diet matched controls
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• decreased muscle glycogen levels at 20 months of age
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• in muscle, resulting in an increase in muscle osmolarity in 24 month old mice
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• increased insulin release at 12 weeks of age
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• at 12 weeks of age
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• increased uptake in skeletal and cardiac muscle at 12 weeks of age
• no change in glucose uptake in white fat, subcutaneous fat, brown fat, or liver
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• at 12 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• do not show glucose intolerance at 12 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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