Phenotypes associated with this allele

• Allele Symbol: Srsf12^em2Cya
• Allele Name: endonuclease-mediated mutation 2, Cyagen Biosciences
• Allele ID: MGI:7586833
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras^+ Srsf12^em2Cya/Srsf12^em2Cya Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * C57BL/6J * FVB/N	MGI:8348361

Genotype
MGI:8348361

cn1

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Srsf12^em2Cya/Srsf12^em2Cya; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:363211 )

• accelerated pancreatic ductal metaplasia at age of 3 months compared to 12 months of age in mutant mice wild-type for Srsf12

• at 3 months of age display larger affected lesion and greater proportion of lat PanINs and PDAC compared to mutant mice wild-type for Srsf12

abnormal tumor morphology ( J:363211 )

• enhanced tumor innervation compared to mutant mice wild-type for Srsf12

abnormal tumor progression ( J:363211 )

• accelerated pancreatic ductal metaplasia at age of 3 months compared to 12 months of age in mutant mice wild-type for Srsf12

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:363211 )

• accelerated pancreatic ductal metaplasia at age of 3 months compared to 12 months of age in mutant mice wild-type for Srsf12

• at 3 months of age display larger affected lesion and greater proportion of lat PanINs and PDAC compared to mutant mice wild-type for Srsf12