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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ido2em2Lamn
endonuclease-mediated mutation 2, Laura Mandik-Nayak
MGI:7579076
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ido2em2Lamn/Ido2em2Lamn involves: BALB/c * C57BL/6J MGI:7579162
cx2
 		Ido2em2Lamn/Ido2em2Lamn
Tg(TcraR28,TcrbR28)KRNDim/0 		involves: C57BL/6 * C57BL/6J * SJL MGI:7579163


Genotype
MGI:7579162
hm1
Allelic
Composition		 Ido2em2Lamn/Ido2em2Lamn
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ido2em2Lamn mutation (0 available); any Ido2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type IV hypersensitivity reaction ( J:342726 )
• minimal inflammatory cell invasion and swelling after sensitizing footpads, abdomen and ears with oxazolone




Genotype
MGI:7579163
cx2
Allelic
Composition		 Ido2em2Lamn/Ido2em2Lamn
Tg(TcraR28,TcrbR28)KRNDim/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ido2em2Lamn mutation (0 available); any Ido2 mutation (40 available)
Tg(TcraR28,TcrbR28)KRNDim mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune arthritis ( J:342726 )
• delayed onset and reduced severity of arthritis: reduced immune cell infiltration, synovial hyperplasia and cartilage erosion

skeleton
autoimmune arthritis ( J:342726 )
• delayed onset and reduced severity of arthritis: reduced immune cell infiltration, synovial hyperplasia and cartilage erosion




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory