All Phenotypes Casp8<em1Hbz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Casp8^em1Hbz
endonuclease-mediated mutation 1, Haibing Zhang
MGI:7572923

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp8^em1Hbz/Casp8^em1Hbz	involves: C57BL/6	MGI:7573087
cx2	Casp8^em1Hbz/Casp8^em1Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7573088
cx3	Casp8^em1Hbz/Casp8^em1Hbz Ripk1^em4Hbz/Ripk1^em4Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7573096
cx4	Casp8^em1Hbz/Casp8^em1Hbz Ripk1^em1Hbz/Ripk1^em1Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7573098
cx5	Casp8^em1Hbz/Casp8^em1Hbz Mlkl^em1Hbz/Mlkl^em1Hbz	involves: C57BL/6	MGI:7573092

Allelic Composition	Casp8^em1Hbz/Casp8^em1Hbz
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^em1Hbz mutation (0 available); any Casp8 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:342732 )

• mild splenomegaly

decreased CD8-positive, alpha-beta T cell number ( J:342732 )

• mild decrease of CD8+ T cell percentage in spleen and bone marrow

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:342732 )

• after treatment with anti-Fas antibody

decreased circulating aspartate transaminase level ( J:342732 )

• after treatment with anti-Fas antibody

cellular

decreased apoptosis ( J:342732 )

• resistance to apoptosis in mouse dermal fibroblasts (MDFs) after treatment with RIPK3 kinase inhibitor GSK872 in vitro

• compromised apoptosis in thymocytes in vitro and increased survival in vivo after treatment with anti-Fas antibody

hematopoietic system

hematopoietic system phenotype ( J:342732 )

N	• normal B cells and myeloid cells in spleen, lymph nodes and bone marrow

enlarged spleen ( J:342732 )

• mild splenomegaly

decreased CD8-positive, alpha-beta T cell number ( J:342732 )

• mild decrease of CD8+ T cell percentage in spleen and bone marrow

growth/size/body

enlarged spleen ( J:342732 )

• mild splenomegaly

mortality/aging

mortality/aging ( J:342732 )

• viable

Allelic Composition	Casp8^em1Hbz/Casp8^em1Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^em1Hbz mutation (0 available); any Casp8 mutation (42 available)
Ripk3^tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:342732 )

increased granulocyte number ( J:342732 )

• increased CD11b+ granulocytes in spleen

• normal in bone marrow

increased CD11b-high dendritic cell number ( J:342732 )

• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow

increased macrophage cell number ( J:342732 )

• in spleen

• normal in bone marrow

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased B cell number ( J:342732 )

• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased T cell number ( J:342732 )

• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen, bone marrow and peripheral blood

hematopoietic system

enlarged spleen ( J:342732 )

increased granulocyte number ( J:342732 )

• increased CD11b+ granulocytes in spleen

• normal in bone marrow

increased CD11b-high dendritic cell number ( J:342732 )

• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow

increased macrophage cell number ( J:342732 )

• in spleen

• normal in bone marrow

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased B cell number ( J:342732 )

• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased T cell number ( J:342732 )

• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen, bone marrow and peripheral blood

growth/size/body

enlarged spleen ( J:342732 )

Allelic Composition	Casp8^em1Hbz/Casp8^em1Hbz Ripk1^em4Hbz/Ripk1^em4Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^em1Hbz mutation (0 available); any Casp8 mutation (42 available)
Ripk1^em4Hbz mutation (0 available); any Ripk1 mutation (31 available)
Ripk3^tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:342732 )

integument

scaly skin ( J:342732 )

skin lesions ( J:342732 )

• focal cutaneous lesions

mortality/aging

preweaning lethality, complete penetrance ( J:342732 )

• mice die by age P14

Allelic Composition	Casp8^em1Hbz/Casp8^em1Hbz Ripk1^em1Hbz/Ripk1^em1Hbz Ripk3^tm1Xidw/Ripk3^tm1Xidw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^em1Hbz mutation (0 available); any Casp8 mutation (42 available)
Ripk1^em1Hbz mutation (0 available); any Ripk1 mutation (31 available)
Ripk3^tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow

decreased T cell number ( J:342732 )

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

immune system

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow

decreased T cell number ( J:342732 )

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

Allelic Composition	Casp8^em1Hbz/Casp8^em1Hbz Mlkl^em1Hbz/Mlkl^em1Hbz
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^em1Hbz mutation (0 available); any Casp8 mutation (42 available)
Mlkl^em1Hbz mutation (0 available); any Mlkl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:342732 )

increased granulocyte number ( J:342732 )

• increased CD11b+ granulocytes in spleen

• normal in bone marrow

increased CD11b-high dendritic cell number ( J:342732 )

• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow

increased macrophage cell number ( J:342732 )

• in spleen

• normal in bone marrow

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased B cell number ( J:342732 )

• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in peripheral blood

decreased T cell number ( J:342732 )

• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in peripheral blood

hematopoietic system

enlarged spleen ( J:342732 )

increased granulocyte number ( J:342732 )

• increased CD11b+ granulocytes in spleen

• normal in bone marrow

increased CD11b-high dendritic cell number ( J:342732 )

• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow

increased macrophage cell number ( J:342732 )

• in spleen

• normal in bone marrow

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased B cell number ( J:342732 )

• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in peripheral blood

decreased T cell number ( J:342732 )

• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in peripheral blood

growth/size/body

enlarged spleen ( J:342732 )

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