Mlkl^em1Hbz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em1Hbz
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Haibing Zhang
• MGI ID: MGI:6449640
• Synonyms: Mlkl^-
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em1Hbz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 301-bp deletion, from the 3' end of intron 1 through the 5' end of exon 2, was introduced by CRISPR/Cas9 genome editing technology. This deletion deletes the exon 2 splice acceptor site and the start codon in exon 2. (J:238962)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 32 strains or lines available

References

• Original: J:238962 Zhang X, et al., MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome. Cell Rep. 2016 Sep 20;16(12):3247-59
• All: 7 reference(s)