Ripk1^em4Hbz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ripk1^em4Hbz
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; endonuclease-mediated mutation 4, Haibing Zhang
• MGI ID: MGI:6449650
• Synonyms: Ripk1^-
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^em4Hbz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 101bp deletion in the coding region of exon 2 was generated using CRISPR-Cas9 genome editing technology with an sgRNA targeting GACCTAGACAGCGGAGGCTT. (J:281166)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 31 strains or lines available

References

• Original: J:281166 Zhang X, et al., Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun. 2019 Sep 13;10(1):4158
• All: 2 reference(s)