Phenotypes associated with this allele

• Allele Symbol: Tbl1xr1^tm1.1Meln
• Allele Name: targeted mutation 1.1, Ari Melnick
• Allele ID: MGI:7550437
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ighg1^tm1(cre)Cgn/Ighg1^+ Tbl1xr1^tm1.1Meln/Tbl1xr1^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550771

Genotype
MGI:7550771

cn1

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Tbl1xr1^tm1.1Meln/Tbl1xr1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)