Phenotypes associated with this allele

• Allele Symbol: Vcan^em1Hwat
• Allele Name: endonuclease-mediated mutation 1, Hideto Watanabe
• Allele ID: MGI:7548796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vcan^em1Hwat/Vcan^em1Hwat	involves: C57BL/6N	MGI:7548843

Genotype
MGI:7548843

hm1

• Allelic Composition: Vcan^em1Hwat/Vcan^em1Hwat
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:298045 )

• in neck, back, fore- and hindlimbs in E16.5 embryos

• ruptures in small vessels in E16.5 embryos

embryo

embryo phenotype ( J:298045 )

N • viable, though viability decreases through continued breeding

decreased embryo size ( J:298045 )

• at E18.5

growth/size/body

decreased embryo size ( J:298045 )

• at E18.5

homeostasis/metabolism

enhanced wound healing ( J:298045 )

• faster wound healing at days 2 and 5

• increased granulation at bottom and margins of wound at days 2 and 7

• increased number of new capillaries in wound at days 2 and 7

• increased level of re-epithelialization in wound at days 5 and 7

• increased number of proliferating cells in wound at day 2

• increased number of CD11b+ cells in wound at day 2 and 5

• increased number of M1 macrophages in wound at day 2

• increased number of CD45+ cells at day 2 and 5 and CD4+ cells at day 2

integument

abnormal dermal layer morphology ( J:298045 )

• fused in hindlimb fused digits

absent epidermis ( J:298045 )

• in hindlimb fused digits

limbs/digits/tail

hindlimb syndactyly ( J:298045 )

• mainly of digits III and IV, with missing epidermis, fused dermis and separated bones

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:298045 )

• some embryos die from organ hemorrhage around E16.5

reproductive system

reproductive system phenotype ( J:298045 )

N • fertile