All Phenotypes Tmem161b<em3Jgg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmem161b^em3Jgg
endonuclease-mediated mutation 3, Joseph G Gleeson
MGI:7520092

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem161b^em3Jgg/Tmem161b^em3Jgg	C57BL/6-Tmem161b^em3Jgg	MGI:7520287
ht2	Tmem161b^em1Jgg/Tmem161b^em3Jgg	C57BL/6-Tmem161b^em1Jgg/Tmem161b^em3Jgg	MGI:7520282
ht3	Tmem161b^em2Jgg/Tmem161b^em3Jgg	C57BL/6-Tmem161b^em2Jgg/Tmem161b^em3Jgg	MGI:7520285

Allelic Composition	Tmem161b^em3Jgg/Tmem161b^em3Jgg
Genetic Background	C57BL/6-Tmem161b^em3Jgg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem161b^em3Jgg mutation (0 available); any Tmem161b mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal jaw morphology ( J:338312 )

• in ~50% E18.5 embryos

acrania ( J:338312 )

• in some E18.5 embryos

downturned snout ( J:338312 )

• in ~50% E18.5 embryos

pigmentation

retina pigment epithelium atrophy ( J:338312 )

• in ~50% E18.5 embryos

vision/eye

retina pigment epithelium atrophy ( J:338312 )

• in ~50% E18.5 embryos

nervous system

abnormal stratification in cerebral cortex ( J:338312 )

• in E18.5 embryos owing to mislocated SATB2+ upper layer neurons into lower layers

thin cerebral cortex ( J:338312 )

• in E18.5 embryos owing to mislocated SATB2+ upper layer neurons into lower layers

absent cerebellum fissure ( J:338312 )

• absent midline longitudinal fissure in ~60% of E18.5 embryos

growth/size/body

abnormal jaw morphology ( J:338312 )

• in ~50% E18.5 embryos

downturned snout ( J:338312 )

• in ~50% E18.5 embryos

microcephaly ( J:338312 )

• in ~50% E18.5 embryos

skeleton

abnormal jaw morphology ( J:338312 )

• in ~50% E18.5 embryos

acrania ( J:338312 )

• in some E18.5 embryos

limbs/digits/tail

limbs/digits/tail phenotype ( J:338312 )

N	• normal limb morphology in E18.5 embryos

Allelic Composition	Tmem161b^em1Jgg/Tmem161b^em3Jgg
Genetic Background	C57BL/6-Tmem161b^em1Jgg/Tmem161b^em3Jgg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem161b^em1Jgg mutation (0 available); any Tmem161b mutation (52 available)
Tmem161b^em3Jgg mutation (0 available); any Tmem161b mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:338312 )

• normal gross brain morphology in E18.5 embryos

abnormal radial glial cell morphology ( J:338312 )

• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos

abnormal stratification in cerebral cortex ( J:338312 )

• in E18.5 embryos owing to mislocated SATB2+ upper layer neurons into progenitor layers

cellular

abnormal radial glial cell morphology ( J:338312 )

• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos

growth/size/body

growth/size/body region phenotype ( J:338312 )

• normal head size in E18.5 embryos

skeleton

skeleton phenotype ( J:338312 )

• normal cranium, jaw and snout morphology in E18.5 embryos

vision/eye

vision/eye phenotype ( J:338312 )

• normal retina pigment epithelium morphology in E18.5 embryos

Allelic Composition	Tmem161b^em2Jgg/Tmem161b^em3Jgg
Genetic Background	C57BL/6-Tmem161b^em2Jgg/Tmem161b^em3Jgg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem161b^em2Jgg mutation (0 available); any Tmem161b mutation (52 available)
Tmem161b^em3Jgg mutation (0 available); any Tmem161b mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:338312 )

• normal gross brain morphology in E18.5 embryos

abnormal radial glial cell morphology ( J:338312 )

• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos

abnormal stratification in cerebral cortex ( J:338312 )

• in E18.5 embryos owing to mislocated SATB2+ upper layer neurons into progenitor layers

cellular

abnormal radial glial cell morphology ( J:338312 )

• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos

growth/size/body

growth/size/body region phenotype ( J:338312 )

• normal head size in E18.5 embryos

skeleton

skeleton phenotype ( J:338312 )

• normal cranium, jaw and snout morphology in E18.5 embryos

vision/eye

vision/eye phenotype ( J:338312 )

• normal retina pigment epithelium morphology in E18.5 embryos

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