About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbl1xr1tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7514121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ighg1tm1(cre)Cgn/Ighg1+
Tbl1xr1tm1c(EUCOMM)Hmgu/Tbl1xr1tm1c(EUCOMM)Hmgu 		involves: 129P2/OlaHsd * C57BL/6J MGI:7550774
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Tbl1xr1tm1c(EUCOMM)Hmgu/Tbl1xr1tm1c(EUCOMM)Hmgu
Tg(Vav-BCL2)69Jad/0 		involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N MGI:7550775


Genotype
MGI:7550774
cn1
Allelic
Composition		 Ighg1tm1(cre)Cgn/Ighg1+
Tbl1xr1tm1c(EUCOMM)Hmgu/Tbl1xr1tm1c(EUCOMM)Hmgu
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Tbl1xr1tm1c(EUCOMM)Hmgu mutation (0 available); any Tbl1xr1 mutation (322 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:292118 )
• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)
• normal B cell abundance
abnormal spleen morphology ( J:292118 )
• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)
• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system
abnormal B cell differentiation ( J:292118 )
• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)
• normal B cell abundance
abnormal spleen morphology ( J:292118 )
• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)
• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)




Genotype
MGI:7550775
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Tbl1xr1tm1c(EUCOMM)Hmgu/Tbl1xr1tm1c(EUCOMM)Hmgu
Tg(Vav-BCL2)69Jad/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Tbl1xr1tm1c(EUCOMM)Hmgu mutation (0 available); any Tbl1xr1 mutation (322 available)
Tg(Vav-BCL2)69Jad mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal lymphocyte morphology ( J:292118 )
• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically
abnormal B cell differentiation ( J:292118 )
• increased number of B220- cells, expressing more CD138 when immunized periodically
• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically
• normal mature B cell numbers in bone marrow when immunized periodically
abnormal spleen morphology ( J:292118 )
• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically

immune system
abnormal lymphocyte morphology ( J:292118 )
• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically
abnormal B cell differentiation ( J:292118 )
• increased number of B220- cells, expressing more CD138 when immunized periodically
• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically
• normal mature B cell numbers in bone marrow when immunized periodically
abnormal spleen morphology ( J:292118 )
• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically

mortality/aging
premature death ( J:292118 )
• when immunized periodically

neoplasm
increased organ/body region tumor incidence ( J:292118 )
• in kidney, lung, liver, intestines and other organs when immunized periodically




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory