All Phenotypes Runx3<tm1.1Itok> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Runx3^tm1.1Itok
targeted mutation 1.1, Kosei Ito
MGI:7482709

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Runx3^tm1.1Itok/Runx3^tm1.1Itok Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:7485832

Allelic Composition	Runx3^tm1.1Itok/Runx3^tm1.1Itok Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3^tm1.1Itok mutation (0 available); any Runx3 mutation (27 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased osteosarcoma incidence ( J:319454 )

• incidence is decreased compared to mutant mice wild-type for Runx3

mortality/aging

increased tumor-free survival time ( J:319454 )

• increased lifespan compared to mutant mice wild-type for Runx3

skeleton

decreased osteosarcoma incidence ( J:319454 )

• incidence is decreased compared to mutant mice wild-type for Runx3

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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