Runx3^tm1.1Itok
Targeted Allele Detail

Summary

• Symbol: Runx3^tm1.1Itok
• Name: runt related transcription factor 3; targeted mutation 1.1, Kosei Ito
• MGI ID: MGI:7482709
• Synonyms: Runx3(P1)^delta
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^tm1.1Itok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319454
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in exon one 5' of the N-terminal region and a loxP and FRT flanked neo cassette was inserted 3' of exon 1. Cre mediated recombination removed the neo cassette and the N-terminal region of exon 1. Western blot analysis confirmed the absence of expression of the RUNX3(P1) protein that has a distinct set of 19 N-terminal amino acids compared to the RUNX3(P2) protein. (J:319454)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 24 strains or lines available

References

• Original: J:319454 Otani S, et al., Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2022 Jan;41(5):683-691
• All: 1 reference(s)