All Phenotypes Ctnna1<em1Xjz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctnna1^em1Xjz
endonuclease-mediated mutation 1, Xianjun Zhu
MGI:7466923

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnna1^em1Xjz/Ctnna1^em1Xjz	C57BL/6J-Ctnna1^em1Xjz	MGI:7467106
cn2	Ctnna1^em1Xjz/Ctnna1^tm1Efu Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA	MGI:7467130

Allelic Composition	Ctnna1^em1Xjz/Ctnna1^em1Xjz
Genetic Background	C57BL/6J-Ctnna1^em1Xjz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1^em1Xjz mutation (0 available); any Ctnna1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:328283 )

• no mice are born

Allelic Composition	Ctnna1^em1Xjz/Ctnna1^tm1Efu Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1^em1Xjz mutation (0 available); any Ctnna1 mutation (133 available)
Ctnna1^tm1Efu mutation (1 available); any Ctnna1 mutation (133 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased angiogenesis ( J:328283 )

• slower growth of horizontal blood vessels in retina at age P7 after tamoxifen administration from age P1-P4

hemorrhage ( J:328283 )

• increased blood vessel leakage in retina at age P7 after tamoxifen administration from age P1-P4

vision/eye

abnormal retina development ( J:328283 )

• slower growth of horizontal blood vessels in retina at age P7 after tamoxifen administration from age P1-P4

• increased blood vessel leakage at age P7 after tamoxifen administration from age P1-P4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:328283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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