All Phenotypes Cap1<tm1.1Mbrst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cap1^tm1.1Mbrst
targeted mutation 1.1, Marco B Rust
MGI:7443056

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cap1^tm1.1Mbrst/Cap1^tm1.1Mbrst Cfl1^tm1.1Wit/Cfl1^tm1.1Wit Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL	MGI:7443115
cn2	Cap1^tm1.1Mbrst/Cap1^tm1.1Mbrst Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:7443114

Allelic Composition	Cap1^tm1.1Mbrst/Cap1^tm1.1Mbrst Cfl1^tm1.1Wit/Cfl1^tm1.1Wit Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cap1^tm1.1Mbrst mutation (0 available); any Cap1 mutation (31 available)
Cfl1^tm1.1Wit mutation (0 available); any Cfl1 mutation (25 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired neuron differentiation ( J:333563 )

• impaired growth cone morphology and motility

nervous system

impaired neuron differentiation ( J:333563 )

• impaired growth cone morphology and motility

Allelic Composition	Cap1^tm1.1Mbrst/Cap1^tm1.1Mbrst Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cap1^tm1.1Mbrst mutation (0 available); any Cap1 mutation (31 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:333563 )

nervous system

impaired neuron differentiation ( J:333563 )

• less fiber tracks in the cortical intermediate zone or in the striatum than in wild-type mice

• impaired neuron differentiation in a cellular system

• impaired growth cone morphology and motility

abnormal hippocampus morphology ( J:333563 )

• determined by Nissl-staining

• however, the cerebral cortex is normal at E18.5

abnormal Ammon gyrus morphology ( J:333563 )

• reduced length

abnormal neurite morphology ( J:333563 )

• reduced length and increased width

• however, neurite numbers and branching are normal

cellular

impaired neuron differentiation ( J:333563 )

• less fiber tracks in the cortical intermediate zone or in the striatum than in wild-type mice

• impaired neuron differentiation in a cellular system

• impaired growth cone morphology and motility

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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