Cap1^tm1.1Mbrst
Targeted Allele Detail

Summary

• Symbol: Cap1^tm1.1Mbrst
• Name: cyclase associated actin cytoskeleton regulatory protein 1; targeted mutation 1.1, Marco B Rust
• MGI ID: MGI:7443056
• Synonyms: CAP1^flx
• Gene: Cap1 Location: Chr4:122752840-122779849 bp, - strand Genetic Position: Chr4, 57.27 cM, cytoband D1
• Alliance: Cap1^tm1.1Mbrst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333563
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT- and loxP-flanked neomycin resistance cassette downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:333563)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cap1 Mutation: 31 strains or lines available

References

• Original: J:333563 Schneider F, et al., Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. Prog Neurobiol. 2021 Jul;202:102050
• All: 2 reference(s)