About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr381em2Kap
endonuclease-mediated mutation 2, Dietmar J Kappes
MGI:7439127
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr381em2Kap/Rr381em2Kap involves: C57BL/6 MGI:7439197
cx2
 		B2mtm1Unc/B2mtm1Unc
Rr381em2Kap/Rr381em2Kap 		involves: 129P2/OlaHsd * C57BL/6 MGI:7439201
cx3
 		H2dlAb1-Ea/H2dlAb1-Ea
Rr381em2Kap/Rr381em2Kap 		involves: 129S2/SvPas * C57BL/6 MGI:7439200
cx4
 		Rr381em2Kap/Rr381em2Kap
Tg(TcraTcrb)1100Mjb/0 		involves: C57BL/6 MGI:7439198
cx5
 		Rr381em2Kap/Rr381em2Kap
Tg(TcrAND)53Hed/0 		involves: C57BL/6 * SJL MGI:7439199


Genotype
MGI:7439197
hm1
Allelic
Composition		 Rr381em2Kap/Rr381em2Kap
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:333471 )
N
• normal single-positive (SP) CD4+ to CD8+ T cell ratio
• normal proportions of SP CD8+ thymocytes and mature CD8+ T cells




Genotype
MGI:7439201
cx2
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Rr381em2Kap/Rr381em2Kap
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (36 available); any B2m mutation (117 available)
Rr381em2Kap mutation (0 available); any Rr381 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:7439200
cx3
Allelic
Composition		 H2dlAb1-Ea/H2dlAb1-Ea
Rr381em2Kap/Rr381em2Kap
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (15 available); any H2 mutation (304 available)
Rr381em2Kap mutation (0 available); any Rr381 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:7439198
cx4
Allelic
Composition		 Rr381em2Kap/Rr381em2Kap
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr381em2Kap mutation (0 available); any Rr381 mutation (0 available)
Tg(TcraTcrb)1100Mjb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:333471 )
N
• normal MHC class-specific T cell development




Genotype
MGI:7439199
cx5
Allelic
Composition		 Rr381em2Kap/Rr381em2Kap
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr381em2Kap mutation (0 available); any Rr381 mutation (0 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:333471 )
N
• normal MHC class-specific T cell development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory