Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Setd5 mutation
(120 available)
Tbx1tm1Bld mutation
(1 available);
any
Tbx1 mutation
(34 available)
Tmem163Tg(ACTB-cre)2Mrt mutation
(3 available);
any
Tmem163 mutation
(35 available)
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mortality/aging
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N |
• double heterozygotes are recovered at normal Mendelian ratios at E14.5
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cardiovascular system
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• at E14.5, 21% of double heterozygotes exhibit an aberrant right subclavian artery
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• at E14.5, 57% of double heterozygotes show OFT rotational defects, including DORV and overriding aorta
• however, no common arterial trunk is identified at E14.5
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• at E14.5, 86% of double heterozygotes exhibit a perimembranous VSD
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Setd5 mutation
(120 available)
Tbx1tm6(cre)Bld mutation
(1 available);
any
Tbx1 mutation
(34 available)
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cardiovascular system
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N |
• at E15.5, hearts show no great vessel defects; outflow tract septation is largely normal and the atrial septum and atrioventricular valves are intact
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
Setd5tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Setd5 mutation
(120 available)
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mortality/aging
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• embryos are recovered at expected Mendelian ratios at E10.5 but die before E12.5
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growth/size/body
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• at E10.5, embryos are significantly smaller than control embryos, as determined by crown-to-rump length
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embryo
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• at E10.5, embryos are significantly smaller than control embryos, as determined by crown-to-rump length
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cardiovascular system
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• at E10.5, all (100%) of hearts exhibit a shorter OFT than control hearts
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• at E10.5, embryos show varying degrees of abnormal cardiac morphogenesis
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• at E10.5, some embryos show poorly developed atria and a thickened atrial wall
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• at E10.5, 25% of embryos have dumbbell-shaped hearts with a single atrium and a single ventricle
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• at E10.5, some embryos exhibit right ventricular hypoplasia
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• at E10.5, some embryos show no evidence of the interventricular groove
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• at E10.5, 74% of embryos exhibit pericardial effusion
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• at E10.5, 95% of embryos show abnormal cardiac chamber ballooning by external analysis
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• at E10.5, all (100%) hearts show abnormal atrial ballooning by H&E analysis
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• at E10.5, all (100%) hearts show abnormal ventricular ballooning by H&E analysis
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• at E10.5, 16% of embryos exhibit hemorrhage
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
Setd5tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Setd5 mutation
(120 available)
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cardiovascular system
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• at E10.5, one of 6 (17%) hearts show abnormal ventricular ballooning
• however, no OFT phenotype or abnormal atrial ballooning is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Setd5 mutation
(120 available)
Tmem163Tg(ACTB-cre)2Mrt mutation
(3 available);
any
Tmem163 mutation
(35 available)
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cardiovascular system
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• at E14.5, 50% of heterozygotes show outflow tract (OFT) rotational defects (OFT fails to align with the two future ventricles at the looping stage), including DORV and overriding aorta
• however, OFT septation is normal; no aberrant right subclavian artery or common arterial trunk are identified at E14.5
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• at E14.5, 75% of heterozygotes exhibit a perimembranous VSD
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Analysis Tools