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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp1b1em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:7425530
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp1b1em1(IMPC)Mbp/Atp1b1em1(IMPC)Mbp C57BL/6NCrl-Atp1b1em1(IMPC)Mbp/Mmucd MGI:7471882
ht2
 		Atp1b1em1(IMPC)Mbp/Atp1b1+ C57BL/6NCrl-Atp1b1em1(IMPC)Mbp/Mmucd MGI:7471881


Genotype
MGI:7471882
hm1
Allelic
Composition		 Atp1b1em1(IMPC)Mbp/Atp1b1em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Atp1b1em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1b1em1(IMPC)Mbp mutation (1 available); any Atp1b1 mutation (20 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Atp1b1em1(IMPC)Mbp/Atp1b1em1(IMPC)Mbp embryos show growth retardation, abnormal embryo turning at E9.5, abnormal head shape, a slight kink in their caudal neural tube and defect in cranial neural tube closure, abnormal heart, and half show branchial arch defects.

cardiovascular system
abnormal heart morphology ( J:211773 , J:374598 )
IMPC - UCD (J:211773)
MGI
• at E9.5, hearts appear abnormal; defects include slight pericardial edema (J:374598)
abnormal heart shape ( J:374598 )
• by E9.5, most homozygous embryos exhibit an abnormal heart shape
pericardial edema ( J:374598 )
• slight pericardial edema is noted at E9.5

craniofacial
abnormal pharyngeal arch morphology ( J:211773 , J:374598 )
IMPC - UCD (J:211773)
MGI
• at E9.5, about half of homozygous embryos display branchial arch defects (J:374598)
abnormal head shape ( J:374598 )
• at E9.5, all homozygous embryos exhibit an abnormal head shape, most prominently in the forebrain

embryo
embryo phenotype ( J:374598 )
N
• at E9.5, placentas are properly developed and comparable to those in control littermates
abnormal pharyngeal arch morphology ( J:211773 , J:374598 )
IMPC - UCD (J:211773)
MGI
• at E9.5, about half of homozygous embryos display branchial arch defects (J:374598)
failure of initiation of embryo turning ( J:374598 )
• at E9.5, some viable homozygous embryos are completely unturned
incomplete embryo turning ( J:374598 )
• at E9.5, some viable homozygous embryos exhibit incomplete turning
embryonic growth retardation ( J:211773 , J:374598 )
IMPC - UCD (J:211773)
MGI (J:374598)
decreased embryo size ( J:374598 )
• at E7.5, homozygous embryos are always among the smallest in their litters
• by E8.5, all homozygous embryos are smaller than control littermates
delayed rostral neuropore closure ( J:374598 )
• at E9.5, most homozygous embryos display defects/delays in cranial neural tube closure
incomplete rostral neuropore closure ( J:374598 )
• at E9.5, most homozygous embryos display defects/delays in cranial neural tube closure
kinked neural tube ( J:374598 )
• at E9.5, all homozygous embryos display a slight kink in their caudal neural tube

growth/size/body
abnormal head shape ( J:374598 )
• at E9.5, all homozygous embryos exhibit an abnormal head shape, most prominently in the forebrain
embryonic growth retardation ( J:211773 , J:374598 )
IMPC - UCD (J:211773)
MGI (J:374598)
decreased embryo size ( J:374598 )
• at E7.5, homozygous embryos are always among the smallest in their litters
• by E8.5, all homozygous embryos are smaller than control littermates

homeostasis/metabolism
pericardial edema ( J:374598 )
• slight pericardial edema is noted at E9.5

limbs/digits/tail
kinked tail ( J:374598 )
• by E10.5, a minority of homozygous embryos exhibit normal head shape and hearts but the last third of the tail is improperly turned/kinked

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:374598 )
• homozygous embryos are present in expected Mendelian ratios at E7.5-E8.5; a minority are resorbing at E9.5 and about one third are dying/resorbed by E10.5
• all homozygous embryos are dying or undergoing resorption by E11.5

nervous system
delayed rostral neuropore closure ( J:374598 )
• at E9.5, most homozygous embryos display defects/delays in cranial neural tube closure
incomplete rostral neuropore closure ( J:374598 )
• at E9.5, most homozygous embryos display defects/delays in cranial neural tube closure
kinked neural tube ( J:374598 )
• at E9.5, all homozygous embryos display a slight kink in their caudal neural tube
abnormal forebrain morphology ( J:374598 )
• at E9.5, all homozygous embryos exhibit an abnormal forebrain shape

vision/eye




Genotype
MGI:7471881
ht2
Allelic
Composition		 Atp1b1em1(IMPC)Mbp/Atp1b1+
Genetic
Background		 C57BL/6NCrl-Atp1b1em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1b1em1(IMPC)Mbp mutation (1 available); any Atp1b1 mutation (20 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system
eye hemorrhage ( J:211773 )
IMPC - UCD

endocrine/exocrine glands
enlarged testis ( J:211773 )
IMPC - UCD

integument

reproductive system
enlarged testis ( J:211773 )
IMPC - UCD

vision/eye
eye hemorrhage ( J:211773 )
IMPC - UCD
cataract ( J:211773 )
IMPC - UCD




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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory