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| Caption | By E8.5, Atp1b1em1(IMPC)Mbp/Atp1b1em1(IMPC)Mbp (Atp1b1-/-) embryos are often delayed compared to litter mates, a minority more severely such as the bottom one displayed above. A similar range of delay is apparent in E9.5 Atp1b1-/- embryos and a minority are resorbing. Those that are viable have not completed the normal turning process, some are completely unturned while the remainder display incomplete turning. All have abnormal head shape, most prominently abnormal forebrain shape. All display a slight kink in their caudal neural tube, most display defect/delays in cranial neural tube closure finally, the hearts are abnormal, including slight pericardial edema. Of those that could be clearly viewed, half display branchial arch defects. By E10.5, a third of Atp1b1-/- embryos are dying/resorbed while others are severely delayed. A minority such as the mutant embryo on the top display normal head shape and hearts but the last third of the tail is improperly turned/kinked. | ||||
| Copyright | This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/09/2025 MGI 6.24 |
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