All Phenotypes Pgbd5<tm1.2Aken> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pgbd5^tm1.2Aken
targeted mutation 1.2, Alex Kentsis
MGI:7334717

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgbd5^tm1.2Aken/Pgbd5^tm1.2Aken	B6J.B6N(FVB)-Pgbd5^tm1.2Aken	MGI:7616754
cn2	Pgbd5^tm1.2Aken/Pgbd5^tm1.2Aken Ptch1^tm1Bjw/Ptch1^tm1Bjw Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW	MGI:7616725
cn3	Pgbd5^tm1.1Aken/Pgbd5^tm1.2Aken Ptch1^tm1Bjw/Ptch1^tm1Bjw Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW	MGI:7616728

Allelic Composition	Pgbd5^tm1.2Aken/Pgbd5^tm1.2Aken
Genetic Background	B6J.B6N(FVB)-Pgbd5^tm1.2Aken

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgbd5^tm1.2Aken mutation (0 available); any Pgbd5 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:346387 )

N	• no defects are detected in the medial cerebellar vermis or lateral hemispheres indicating normal cerebellar development • expression analysis did not detect any abnormalities in SHH pathway activity in isolated granule cell precursors

Allelic Composition	Pgbd5^tm1.2Aken/Pgbd5^tm1.2Aken Ptch1^tm1Bjw/Ptch1^tm1Bjw Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgbd5^tm1.2Aken mutation (0 available); any Pgbd5 mutation (33 available)
Ptch1^tm1Bjw mutation (2 available); any Ptch1 mutation (115 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased tumor-free survival time ( J:346387 )

• increased survival compared to mutant mice wild-type for Pgbd5

neoplasm

decreased classified tumor incidence ( J:346387 )

• up to 70% of mice do not develop medulloblastomas at up to 1 year of life while 79% of mutant mice wild-type for Pgdb5 rapidly develop medulloblastomas

Allelic Composition	Pgbd5^tm1.1Aken/Pgbd5^tm1.2Aken Ptch1^tm1Bjw/Ptch1^tm1Bjw Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgbd5^tm1.1Aken mutation (1 available); any Pgbd5 mutation (33 available)
Pgbd5^tm1.2Aken mutation (0 available); any Pgbd5 mutation (33 available)
Ptch1^tm1Bjw mutation (2 available); any Ptch1 mutation (115 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased medulloblastoma incidence ( J:346387 )

• develop tumors with a similar latency to mice with one wild-type Pgbd5 allele, but most tumors retain an unrecombined floxed Pgbd5 allele

nervous system

increased medulloblastoma incidence ( J:346387 )

• develop tumors with a similar latency to mice with one wild-type Pgbd5 allele, but most tumors retain an unrecombined floxed Pgbd5 allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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