About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpap3tm1c(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:7310425
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:7310428
cn2
 		Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Tg(Vil1-cre/ERT2)23Syr/0
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6N * DBA/2 MGI:7310427
cn3
 		Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Tg(Vil1-cre/ERT2)23Syr/0 		involves: C57BL/6N * DBA/2 MGI:7310426


Genotype
MGI:7310428
cn1
Allelic
Composition		 Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (57 available)
Rpap3tm1c(KOMP)Wtsi mutation (0 available); any Rpap3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:314346 )
• tamoxifen-treated mice are normal and survive for 3 weeks at least




Genotype
MGI:7310427
cn2
Allelic
Composition		 Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Tg(Vil1-cre/ERT2)23Syr/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpap3tm1c(KOMP)Wtsi mutation (0 available); any Rpap3 mutation (34 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine morphology ( J:314346 )
• tamoxifen-treated mice exhibit a delay in epithelium shrinkage compared mice with at least one copy of wild-type Trp53
decreased small intestine length ( J:314346 )
• in tamoxifen-treated mice after 7 days




Genotype
MGI:7310426
cn3
Allelic
Composition		 Rpap3tm1c(KOMP)Wtsi/Rpap3tm1c(KOMP)Wtsi
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpap3tm1c(KOMP)Wtsi mutation (0 available); any Rpap3 mutation (34 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal enterocyte morphology ( J:314346 )
• disorganized with focal crowding in tamoxifen-treated mice after 7 days
abnormal small intestine morphology ( J:314346 )
• in tamoxifen-treated mice after 6 days
abnormal small intestine goblet cell morphology ( J:314346 )
• in tamoxifen-treated mice after 7 days
decreased small intestine length ( J:314346 )
• in tamoxifen-treated mice after 6 days
abnormal intestinal epithelium physiology ( J:314346 )
• tamoxifen-treated mice exhibit reduction in proliferating stem cells and progenitors and increased apoptosis compared with control mice
• however, differentiated Paneth cells are normal
small intestinal inflammation ( J:314346 )
• after 6 days, tamoxifen-treated mice exhibit massive intestinal swelling with a transparent liquid or blood compared with control mice

growth/size/body
weight loss ( J:314346 )
• in tamoxifen-treated mice after 6 days

immune system
small intestinal inflammation ( J:314346 )
• after 6 days, tamoxifen-treated mice exhibit massive intestinal swelling with a transparent liquid or blood compared with control mice

cellular
abnormal small intestine goblet cell morphology ( J:314346 )
• in tamoxifen-treated mice after 7 days




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory