Phenotypes associated with this allele

• Allele Symbol: Usp39^em1Imat
• Allele Name: endonuclease-mediated mutation 1, Isao Matsuo
• Allele ID: MGI:7287389
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp39^em1Imat/Usp39^em1Imat	CD1-Usp39^em1Imat	MGI:7287414
cx2	Uba1^em1Imat/Uba1^+ Usp39^em1Imat/Usp39^em1Imat	CD1-Usp39^em1Imat Uba1^em1Imat	MGI:7287418
cx3	Grhl3^tm1(cre)Cgh/Grhl3^+ Usp39^em1Imat/Usp39^+	involves: 129P2/OlaHsd * CD-1	MGI:7287462
cx4	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh Usp39^em1Imat/Usp39^+	involves: 129P2/OlaHsd * CD-1	MGI:7287463
cx5	Usp39^em1Imat/Usp39^+ Vangl2^Lp/Vangl2^Lp	involves: A * CD-1	MGI:7287423

Genotype
MGI:7287414

hm1

• Allelic Composition: Usp39^em1Imat/Usp39^em1Imat
• Genetic Background: CD1-Usp39^em1Imat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:324183 )

embryo

abnormal developmental patterning ( J:324183 )

• severely compromised posterior patterning

abnormal mesoderm development ( J:324183 )

• embryonic mesoderm failed to form at E6.5

abnormal embryo morphology ( J:324183 )

• compact with a failure to form a primitive streak

abnormal embryonic epiblast morphology ( J:324183 )

• aberrant apico-basal polarity

failure of primitive streak formation ( J:324183 )

Genotype
MGI:7287418

cx2

• Allelic Composition: Uba1^em1Imat/Uba1⁺; Usp39^em1Imat/Usp39^em1Imat
• Genetic Background: CD1-Usp39^em1Imat Uba1^em1Imat

embryo

abnormal primitive streak formation ( J:324183 )

• partial at E6.5 with mesoderm cells migrating toward the anterior side unlike in Usp39^em1Imat homozygotes

Genotype
MGI:7287462

cx3

• Allelic Composition: Grhl3^tm1(cre)Cgh/Grhl3⁺; Usp39^em1Imat/Usp39⁺
• Genetic Background: involves: 129P2/OlaHsd * CD-1

integument

abnormal hair growth ( J:324183 )

• hair fails to grow on thickened scaly skin

scaly skin ( J:324183 )

• thickened scaly skin in some mice

thick skin ( J:324183 )

• thickened scaly skin in some mice

Genotype
MGI:7287463

cx4

• Allelic Composition: Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh; Usp39^em1Imat/Usp39⁺
• Genetic Background: involves: 129P2/OlaHsd * CD-1

vision/eye

failure of eyelid fusion ( J:324183 )

• at increased frequency compared with Grhl3^tm1(cre)Cgh homozygotes at E15.5

Genotype
MGI:7287423

cx5

• Allelic Composition: Usp39^em1Imat/Usp39⁺; Vangl2^Lp/Vangl2^Lp
• Genetic Background: involves: A * CD-1

embryo

short rostral-caudal axis ( J:324183 )

• shorter than in Vangl2^Lp homozygotes

limbs/digits/tail

abnormal limb development ( J:324183 )

• precocious hindlimb induction