All Phenotypes Usp39<em1Imat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Usp39^em1Imat
endonuclease-mediated mutation 1, Isao Matsuo
MGI:7287389

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp39^em1Imat/Usp39^em1Imat	CD1-Usp39^em1Imat	MGI:7287414
cx2	Uba1^em1Imat/Uba1⁺ Usp39^em1Imat/Usp39^em1Imat	CD1-Usp39^em1Imat Uba1^em1Imat	MGI:7287418
cx3	Grhl3^tm1(cre)Cgh/Grhl3⁺ Usp39^em1Imat/Usp39⁺	involves: 129P2/OlaHsd * CD-1	MGI:7287462
cx4	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh Usp39^em1Imat/Usp39⁺	involves: 129P2/OlaHsd * CD-1	MGI:7287463
cx5	Usp39^em1Imat/Usp39⁺ Vangl2^Lp/Vangl2^Lp	involves: A * CD-1	MGI:7287423

Allelic Composition	Usp39^em1Imat/Usp39^em1Imat
Genetic Background	CD1-Usp39^em1Imat

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp39^em1Imat mutation (0 available); any Usp39 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:324183 )

embryo

abnormal developmental patterning ( J:324183 )

• severely compromised posterior patterning

abnormal mesoderm development ( J:324183 )

• embryonic mesoderm failed to form at E6.5

abnormal embryo morphology ( J:324183 )

• compact with a failure to form a primitive streak

abnormal embryonic epiblast morphology ( J:324183 )

• aberrant apico-basal polarity

failure of primitive streak formation ( J:324183 )

Allelic Composition	Uba1^em1Imat/Uba1⁺ Usp39^em1Imat/Usp39^em1Imat
Genetic Background	CD1-Usp39^em1Imat Uba1^em1Imat

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uba1^em1Imat mutation (0 available); any Uba1 mutation (3 available)
Usp39^em1Imat mutation (0 available); any Usp39 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal primitive streak formation ( J:324183 )

• partial at E6.5 with mesoderm cells migrating toward the anterior side unlike in Usp39^em1Imat homozygotes

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Usp39^em1Imat/Usp39⁺
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Usp39^em1Imat mutation (0 available); any Usp39 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:324183 )

• hair fails to grow on thickened scaly skin

scaly skin ( J:324183 )

• thickened scaly skin in some mice

thick skin ( J:324183 )

• thickened scaly skin in some mice

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh Usp39^em1Imat/Usp39⁺
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

failure of eyelid fusion ( J:324183 )

• at increased frequency compared with Grhl3^tm1(cre)Cgh homozygotes at E15.5

Allelic Composition	Usp39^em1Imat/Usp39⁺ Vangl2^Lp/Vangl2^Lp
Genetic Background	involves: A * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp39^em1Imat mutation (0 available); any Usp39 mutation (25 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

short rostral-caudal axis ( J:324183 )

• shorter than in Vangl2^Lp homozygotes

limbs/digits/tail

abnormal limb development ( J:324183 )

• precocious hindlimb induction

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