Phenotypes associated with this allele

• Allele Symbol: En1^em1Smun
• Allele Name: endonuclease-mediated mutation 1, Stefan Mundlos
• Allele ID: MGI:6740432
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	En1^em1Smun/En1^em1Smun	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:6740445
cx2	En1^em1Smun/En1^+ Gm29348^em4Smun/Gm29348^+	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:6740444

Genotype
MGI:6740445

hm1

• Allelic Composition: En1^em1Smun/En1^em1Smun
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased sternebra size ( J:306235 )

• with reduced and irregular intercostal ossification

short sternum ( J:306235 )

• truncated

abnormal rib morphology ( J:306235 )

• abnormal placement of the ribs

limbs/digits/tail

polydactyly ( J:306235 )

• ectopic ventral digits (VI) fused at the level of phalanges 1 and 3

syndactyly ( J:306235 )

• 3rd and 4th digits at the level of phalanges 3, 2, and 1

Genotype
MGI:6740444

cx2

• Allelic Composition: En1^em1Smun/En1⁺; Gm29348^em4Smun/Gm29348⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

limbs/digits/tail

abnormal limb morphology ( J:306235 )

• severe double dorsal-limb defects

nervous system

nervous system phenotype ( J:306235 )

N • mice exhibit normal brains

skeleton

skeleton phenotype ( J:306235 )

N • mice exhibit normal sternum and ribs