En1^em1Smun
Endonuclease-mediated Allele Detail

Summary

• Symbol: En1^em1Smun
• Name: engrailed 1; endonuclease-mediated mutation 1, Stefan Mundlos
• MGI ID: MGI:6740432
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^em1Smun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306235
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted the promoter region. (J:306235)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 32 strains or lines available

References

• Original: J:306235 Allou L, et al., Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator. Nature. 2021 Apr;592(7852):93-98
• All: 1 reference(s)