Phenotypes associated with this allele

• Allele Symbol: Hilpda^tm1Xen
• Allele Name: targeted mutation 1, Taconic Biosciences
• Allele ID: MGI:6724249
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hilpda^tm1Xen/Hilpda^tm1Xen	C57BL/6-Hilpda^tm1Xen	MGI:6724257

Genotype
MGI:6724257

hm1

• Allelic Composition: Hilpda^tm1Xen/Hilpda^tm1Xen
• Genetic Background: C57BL/6-Hilpda^tm1Xen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:301866 )

N • mice exhibit normal respiratory exchange ratio (at 22 and 30 degrees Celsius), oxidation of carbohydrates and fats, and glucose tolerance

impaired adaptive thermogenesis ( J:301866 )

• in fasted mice

• however, fed mice exhibit normal thermoregulation

increased circulating HDL cholesterol level ( J:301866 )

• in fasted mice

decreased body temperature ( J:301866 )

• in fasted mice

decreased energy expenditure ( J:301866 )

• at 22 degrees Celsius but not at 30 or 4 degrees Celsius

• in fasted mice

decreased oxygen consumption ( J:301866 )

• at 22 degrees Celsius but not at 30 or 4 degrees Celsius

• in fasted mice

behavior/neurological

decreased food intake ( J:301866 )

• despite normal body weight

increased food intake ( J:301866 )

• in cold exposed mice

decreased vertical activity ( J:301866 )

decreased locomotor activity ( J:301866 )

• at 22 degrees Celsius but not at 30 or 4 degrees Celsius

adipose tissue

adipose tissue phenotype ( J:301866 )

N • mice exhibit normal mitochondrial fuel oxidation and triglyceride hydrolysis in the presence of high levels of nutrients in brown adipose tissue and body temperature in cold exposed fed mice