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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dhcr24tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6715348
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dhcr24tm1c(EUCOMM)Wtsi/Dhcr24tm1c(EUCOMM)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		B6.Cg-Dhcr24tm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn MGI:6715351
cn2
 		Dhcr24tm1c(EUCOMM)Wtsi/Dhcr24tm1c(EUCOMM)Wtsi
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * C57BL/6N MGI:6715491


Genotype
MGI:6715351
cn1
Allelic
Composition		 Dhcr24tm1c(EUCOMM)Wtsi/Dhcr24tm1c(EUCOMM)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 B6.Cg-Dhcr24tm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhcr24tm1c(EUCOMM)Wtsi mutation (0 available); any Dhcr24 mutation (33 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal sterol level ( J:304449 )
• mice exhibit elevated liver, plasma, stool, and biliary levels of desmosterol
• mice exhibit slightly elevated lanosterol levels in the liver
• however, circulating levels of cholesterol are normal, sterol levels in the brains show no differences in cholesterol or desmosterol levels, and no changes in the levels of stool cholesterol are seen
decreased liver cholesterol level ( J:304449 )
• hepatic cholesterol levels are slightly decreased in females

liver/biliary system
abnormal liver morphology ( J:304449 )
• liver shows elevated desmosterol level and slightly elevated lanosterol levels
• however, no differences are seen in liver cell morphology or hepatic lipid accumulation
decreased liver cholesterol level ( J:304449 )
• hepatic cholesterol levels are slightly decreased in females
abnormal bile composition ( J:304449 )
• biliary desmosterol level is increased
• however, no differences in levels of biliary cholesterol, bile acids or biliary phospholipids are seen

digestive/alimentary system
abnormal feces composition ( J:304449 )
• stool desmosterol level is increased




Genotype
MGI:6715491
cn2
Allelic
Composition		 Dhcr24tm1c(EUCOMM)Wtsi/Dhcr24tm1c(EUCOMM)Wtsi
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhcr24tm1c(EUCOMM)Wtsi mutation (0 available); any Dhcr24 mutation (33 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal sterol level ( J:304449 )
• tamoxifen-treated mice show a very large increase in plasma desmosterol level
• liver, brain, and heart tissue desmosterol levels are elevated in tamoxifen-treated mice
• however, liver, brain and heart tissue cholesterol levels in tamoxifen-treated mice are normal
decreased circulating cholesterol level ( J:304449 )
• mice treated with tamoxifen at 4-5 weeks of age show an early decline and stable decrease in plasma cholesterol
• however, cholesterol content of liver, brain, and heart is normal

liver/biliary system
abnormal bile composition ( J:304449 )
• bile shows elevated desmosterol levels in tamoxifen-treated mice
• tamoxifen-treated mice show lower biliary cholesterol level




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory